This project is directed towards the development of novel chemical tools to control the bioactivity of small molecules within cancer cells. These compounds will assist both in deciphering the biological pathways that lead to cancer as well as allowing the targeted treatment of diseased tissues.
The primary focus of this research programme will be to manipulate DNA methylation patterns, as it is known that aberrant methylation leads to cancer, but modulation of DNA methylation using small molecules is currently not possible. Successful preparation of molecules capable of manipulating DNA methylation would be extremely valuable biological tools and have enormous potential as therapeutic agents.
The project will encompass the chemical synthesis of the research reagents and their characterization using classical spectroscopic techniques as well as biochemical, epigenetic and cell biological assays.
The PhD candidate will receive training within the internationally recognized research groups within UCL Chemistry and via the wider UCL PhD training programme.
Qualifications
We are seeking a highly motivated and ambitious candidate with a strong background in chemistry or biological chemistry holding, or expecting to obtain, a minimum upper-second class honours degree in chemistry.
Excellent experimental and analytical skills in chemistry are required, as well as an interest in learning cell biological techniques. The project is funded for 3 years and will be supervised by Dr. Stefan Howorka, Dr. Jon Wilden, (UCL Chemistry), and Prof. Stephan Beck (UCL Cancer Institute). The studentship provides a tax-free stipend (£16,180 pa) in addition to covering tuition fees at the UK/EU rate.
Application details
Formal applications should be submitted in the form of a CV and covering letter outlining motivation, interest, and suitability for this project to Dr. Stefan Howorka at s.howorka@ucl.ac.uk. Details for three references should also be provided. Informal enquiries may be made to Dr. Howorka.
Closing date: 15 May 2015
University College London
Department of Chemistry