Project title: “ITLIVER: Strategy to Inhibit TGFβ in Liver Disease” Marie Curie Initial Training Network (ITN) Job description: An Experienced Researcher position is available to study the molecular basis of subverted TGFβ signal transduction in liver diseases. Our group is interested in unraveling mechanisms by which TGFβ family members elicit their multifunctional cellular effects and how perturbation in their signal transduction pathways contribute to diseases.
We use mouse and zebrafish models. Our long term aim is to translate our findings towards the development of novel treatments. Misregulation of TGFβ signalling has been implicated in many different diseases, including liver fibrosis. We like to target the abnormal TGFβ signaling and normalize liver fibrosis using in vitro studies and animal models. In addition to mechanistic studies on novel identified regulators of TGFβ signaling, their importance in disease will be investigated using human clinical samples and expression profiling studies with publicly available data bases.
The specific aims of the ITN Training programme are to: Provide talented earlystage (PhD) and experienced researchers (Post doctoral) a research training programme aimed at acquisition of: stateoftheart knowledge of the components of the skills spectrum needed to combat CLD, i.e. science and technologies of basic molecular liver cell biology, drug discovery and delivery systems and development of preclinical models and (pre)clinical treatment modalities; the ability to assimilate the individual components of the skills spectrum such that they will be able to oversee and in a goaloriented manner direct the multisectorial process of combating diseases in general, but CLD in particular.
Improve employability of its trainees in the higher ranks of academia and industry by enhancing their transferable skills e.g. in writing, communication, intellectual property management, valorisation and entrepreneurship. Strengthen intersectorial research cooperation to advance our understanding of the molecular and cellular mechanisms of CLD progression and to translate this knowledge into drug discovery and treatment modalities.
Qualification:
Job starting date: 01/09/2015
Application deadline: 30/06/2015
More information: Tiziana Cubeddu International Research and Mobility Programs Office tel. +39 070 675 8442 fax +39 070 675 8450
Email: tcubeddu@amm.unica.it
bandi.internazionali@unica.it