Bioinorganic Chemistry and medicinal chemistry Postdoctoral Positions

Applications are invited for a Postdoctoral position in bioinorganic and medicinal chemistry. The position is in the framework of the cooperative project about “oxidation of the amyloid peptide and implication in the etiology of Alzheimer’s Disease” between the group of Fabrice Collin (PharmaDev, Toulouse) and Christelle Hureau / Peter Faller (LCC Toulouse) funded by the French national agency ANR.

Project: A defining feature in Alzheimer’s Disease is the post-mortem observation of senile plaques, mainly composed of the amyloid-beta peptide (A), along with metal ions (Cu, Fe, Zn). Aggregation of A is a critical step in the development of AD and intermediates seem to mediate oxidative stress via the production of reactive oxygen species (ROS). Moreover, copper can both catalyze efficiently the generation of ROS and also influence the aggregation of A. Thus, the complexes A/Cu might be the cross point of ROS production and A aggregation linked to A-induced toxicity in AD. By a multidisciplinary approach at the frontiers of chemistry, biology and living systems, the project aims at studying the relation between copper-induced aggregation A and their consequences on ROS production.

Profile of the candidate: The candidates should preferentially have a background in chemistry or biochemistry, preferentially in bioinorganic chemistry and should have a strong interest in interdisciplinary research (chemistry, spectroscopy, biology). Experience in research on amyloidogenic peptides

Net salary: ~1800 Euros per month

The candidates should contact Peter Faller and Christelle Hureau (+33 5 61 33 31 62) with copy to Fabrice Collin, (+33 5 62 25 98 11).

Closing date: until filled

Lab : Laboratoire de Chimie de Coordination and PharmaDev, Toulouse (France)

Web :

Laboratoire de Chimie de Coordination and PharmaDev, Toulouse (France),