2 PhD positions: Chemistry, Biochemistry, Molecular Biology 1008 views

Heidelberg University is offering a PhD position under the Project supervisor Barends, Thomas. The start of PhD project will be 1 Jul 2020. Applications are open to two outstanding PhD students to investigate enzymes involved in lipid biosynthesis in ladderane-producing microorganisms. The PhD students will express these enzymes both separately to perform crystallographic and biochemical studies, and in combination to establish an in-vivo system for the investigation of the biosynthetic pathway of ladderanes.

About the Project:
  • Title of the project is Ladderane Lipid BiosynthesisSummary: Ladderanes are highly unusual hydrocarbon moieties with linearly concatenated cyclobutane rings. They are found in the membranes of bacteria performing anaerobic ammonium oxidation (“anammox”).
  • How these complicated molecules are produced is expected to involve both novel enzymes and specially evolved versions of known proteins, but the details remain enigmatic.
  • How do these enzymes assemble such intricate carbon skeletons? How do they control the complex stereochemistry involved?
  • How do they deal with the typical nonreactivity of hydrocarbons?
  • How do they overcome the ring strain inherent in these molecules?
  • Answering these and other questions about the molecular mechanism of ladderane biosynthesis will open up new frontiers in enzymology.

Qualifications:

  • Candidate must hold a university degree in Chemistry, Biochemistry, Molecular Biology or related field.
  • Experience with iron-sulfur cluster proteins is a welcome plus.
  • Applicants should have good English writing and communication skills.
  • Candidate must be highly motivated, open-minded, and capable of critical and analytical thinking.
—————–Quick Overview————-
Organization Heidelberg University
Country Germany
Fellowship Level Doctoral
Subject areas Chemistry, Biochemistry, Molecular Biology
Fellowship amount Varies
Eligibility Master’s degree
Deadline 31 May 2020
————————————

Company Information
  • Total Jobs 500 Jobs
  • Address India

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