European Research Council Life science PhD scholarships 3684 views

Competitive scholarships for Ph.D. students are available. You will work in a team of young investigators that challenge some long-standing problems in the field of hematology. We do basic and translational science, but with the objective to help patients in the future

Position 1:          NON-CODING RNAs (microRNAS/lncRNAS) AND MICROENVIRONMENTAL INTERACTIONS OF MALIGNANT B-CELLS

Supervisor: Assoc. Prof. Marek Mraz, MSc., M.D., Ph.D.

1. We are looking for a motivated Ph.D. student that would like to work on the following project funded by the ERC (European Research Council) Starting grant. It is now understood that the B-cell receptor (BCR) signaling is the key pathway deregulated during the onset of many B cell leukemias and lymphomas. BCR signaling is also considered the most promising target for therapy in B cell malignancies.
2. WHO ARE WE LOOKING FOR:
   1. Motivated smart people that have the “drive” to work independently, but also willing to learn from other people in the lab and collaborate.
   2. Candidates should have a master’s degree in Molecular biology, Biochemistry, or similar field and have deep interest in molecular biology and cancer cell biology.
3. HOW TO APPLY:
   1. To apply please contact the supervisor and submit a CV by email to marek.mraz@email.cz (Subject: Ph.D. School).
   2. Information about the laboratory at: ceitec.cz/mrazlab; apply before 15 Feb 2020 for starting Sept 2020

Position 2:          MIGRATION OF MALIGNANT B CELLS AND THEIR ADAPTIVE RESPONSE TO BCR INHIBITOR THERAPY

Supervisor: Assoc. Prof. Marek Mraz, MSc., M.D., Ph.D.

1. We are looking for a motivated Ph.D. student that would like to work on the following project funded by the ERC (European Research Council) Starting grant. Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and it seems that its pathogenesis is not directly driven by a mutation or genomic aberration. We and others have described that CLL cells are dependent on constant re-circulation between peripheral blood and lymph nodes where they obtain pro-survival and pro-proliferative signals.
2. WHO ARE WE LOOKING FOR:
   1. Motivated smart people that have the “drive” to work independently, but also willing to learn from other people in the lab and collaborate.
   2. Candidates should have a master’s degree in Molecular biology, Biochemistry, or similar field and have a deep interest in molecular biology and cancer cell biology.
3. HOW TO APPLY:
   1. To apply please contact the supervisor and submit a CV by email to marek.mraz@email.cz (Subject: Ph.D. School).
   2. Information about the laboratory at ceitec.cz/mrazlab; apply before 15 Feb 2020 for starting Sept 2020

Positions 3:        LONG NON-CODING RNAs (lncRNAs) IN THE PATHOGENESIS OF B CELL LYMPHOMAS Supervisor: Assoc. Prof. Marek Mraz, MSc., M.D., Ph.D.

1. We are looking for a motivated Ph.D. student that would like to work on the following project funded by the ERC (European Research Council) Starting grant. Follicular lymphoma (FL) is a type of blood cancer that originates from B-lymphocytes, and it is the most common type of indolent non-Hodgkin lymphoma. The clinical course of FL patients can be surprisingly variable (survival from months to decades) and FL still remains incurable.
2. The course of the disease is characterized by repeated relapses leading to the evolution of resistant disease or to the high-grade transformation to a more aggressive diffuse large B-cell lymphoma (DLBCL). This is associated with remarkably poor prognosis and a high risk of early death.
3. WHO ARE WE LOOKING FOR:
   1. Motivated smart people that have the “drive” to work independently, but also willing to learn from other people in the lab and collaborate.
   2. Candidates should have a master’s degree in Molecular biology, Biochemistry, or similar field and have a deep interest in molecular biology and cancer cell biology.
4. HOW TO APPLY:
   1. To apply please contact the supervisor and submit a CV by email to marek.mraz@email.cz (Subject: Ph.D. School).
   2. Information about the laboratory at: ceitec.cz/mrazlab; apply before 15 Feb 2020 for starting Sept 2020

Position 4: REGULATION OF BCR SIGNALLING BY DNA DAMAGE RESPONSE AND P53 PROTEIN

Supervisor: Assoc. Prof. Marek Mraz, MSc., M.D., Ph.D. PROJECT:

1. We are looking for a motivated Ph.D. student that would like to work on the following project funded by the ERC (European Research Council) Starting grant. The variable clinical course of several B cell malignancies largely depends on p53 functionality and B-cell receptor (BCR) signaling propensity; however, it is unclear if there is any crosstalk between these pathways.
2. WHO ARE WE LOOKING FOR:
   1. Motivated smart people that have the “drive” to work independently, but also willing to learn from other people in the lab and collaborate.
   2. Candidates should have a master’s degree in Molecular biology, Biochemistry, or similar field and have a deep interest in molecular biology and cancer cell biology.
3. HOW TO APPLY:
4. To apply please contact the supervisor and submit a CV by email to marek.mraz@email.cz (Subject: Ph.D. School).
5. Information about the laboratory at ceitec.cz/mrazlab; apply before 15 Feb 2020 for starting Sept 2020

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