International PhD Program in Protein Biotechnology 1375 views

BioToP (Biomolecular Technology of Proteins) is offering an inter- and multi-disciplinary research-based doctoral education at the interface of basic and applied science in the field of protein biotechnology.

Research fields:

• structure-function analysis, engineering and design of proteins
• protein synthesis, targeting and post-translational modifications
• expression systems and cell factories
• bioinformatics and molecular modelling

Requirements:

• Highly qualified applicants from all over the world are welcome to apply.
• Applicants must hold an undergraduate degree equivalent to a master (corresponding to 300 ECTS) which would qualify them to start a PhD thesis in their home country.
• Candidates who have not yet obtained their degree will be accepted if they will finish their studies latest by the end of August 2019.
• Applicants with only a bachelor degree (B.S.) or similar are not eligible.
• There is no strict age limit, however applicants should not be older than 30 years.
• PhD students applying for a wet-lab research project must have a master degree in biological sciences, biotechnology, chemistry, medicine or closely related subjects.
• PhD students applying for a dry-lab research project must have a master degree in a technical or scientific discipline.
• Applicants must be fluent in both spoken and written English.

How to apply

• Application Form to be sent via Email to biotop(at)boku.ac.at together with all enclosures:
• Copy of diploma or masters certificate (if already available)
• Copy of certificates obtained for coursework including grades (transcript of records of bachelor and master studies)
• Copy of passport
• Letters of recommendation are requested from two scientists.

List of all open PhD research projects

Open Projects:

1. Oxygen reactivity in the flavin-dependent enzyme pyranose oxidase
2. Increasing thermostability of pyranose oxidase by enzyme evolution
3. Substrate specificity in carbohydrate oxidoreductases
4. Cytochromes as electron transfer mediators for bioelectrodes
5. Allosteric molecular recognition to improve tumor specificity
6. Unbreakable – introducing different enzymatic functions into a highly stable heme-binding protein from Sulfolobus solfataricus
7. Methylated N-glycans in moss – annoying or useful for biotechnology?
8. Exact structures of cross-reactive carbohydrate determinants of insect and seafood allergens
9. Nsun5 methylates rRNA: ‘specialized’ ribosomes in stress resistance and aging
10. Extracellular vesicles as drug-targeting vehicle
11. Development of selective inhibitors for plant subtilisin-like serine proteases
12. Isolation and characterization of proteases involved in recombinant protein processing in insect cells
13. Structure and Function of Hexosaminidases
14. Microarrays of natural and remodelled glycans
15. Synthetic biology tools to control expression of multiple genes in a pathway
16. Mechanisms of control of endogenous gene expression
17. Extracellular micro vesicles and exosomes and their role in the insect cell-baculovirus expression system
18. Inducible regulation of baculovirus genes involved in secretion and virus budding
19. Cellular limitations of poor protein secretion in mammalian cells
20. Impact of extrinsic production factors on mammalian cell production performance
21. Control of glycolysis in Crabtree-negative and positive yeasts
22. Folding of recombinant bacterial RuBisCO
23. In planta engineering and functional activities of oligo-sialic acid
24. Engineering and functional activities of polysialylated IgG antibodies
25. Designed protein storage organelles and their uptake into target cells
26. Modulating ER morphology and stress to boost recombinant protein accumulation
27. The effect of mechanical rigidity on the entrapment of bionanoparticles in narrow channels
28. Protein solubility in buffers with kosmotropic salts and polyols
29. Simulation of proteins in realistic environments
30. Thermodynamics for allosteric modulation