PhD and postdoc positions: Medicinal Chemistry, Epigenetics, Protein Engineering 2275 views

The Department of Chemistry, Department of Molecular Mechanisms of Disease, Department of Biochemistry at University of Zurich invite applications for 1 PhD student position in Medicinal Chemistry, 1 PhD student and 1 Postdoc position in Epigenetics and Gene Regulation, 1 PhD student or Postdoc position in Protein Engineering and Crystallography. The positions are available from 2nd half 2018 or as soon as possible

Responsibilities:

• 1 PhD student in Medicinal Chemistry (Nevado Lab, Department of Chemistry): rational design and synthesis of novel, complex molecular scaffolds and the evaluation of their biological activity in diverse in vitro/in vivo models.
• 1 PhD student and 1 Postdoc position in Epigenetics and Gene Regulation (Baubec Lab, Department of Molecular Mechanisms of Disease): dissecting the consequences of bromodomain-inhibition on chromatin and transcription in stem cells and during their neuronal differentiation using genome-wide readouts and bioinformatics analysis. Experience in epigenetics, gene regulation and/or bioinformatics will be particularly valued.
• 1 PhD student or Postdoc in Protein Engineering and Crystallography (Caflisch Lab, Department of Biochemistry): engineering of bromodomains to modulate ligand-selectivity. Solving the crystal structures of the wild type and engineered proteins (unbound and ligand-complexed) will guide medicinal chemistry activities. Experience in protein biochemistry is required; experience in protein crystallography is not requested.

Qualifications:

• Applicant must hold Bachelor/Master in Organic Chemistry at the time of submission of applications.
• Applicants must have a solid knowledge and practical experience in organic chemistry and be familiar with techniques such as NMR, UV-Vis, IR, MS, etc.
• Applicants with previous experience in the area of chemical biology (cellular and biophysical assays, protein production and crystallography, etc.) will be a plus.

Duration: PhD, 3 (+1) years; Postdoc, 1 (+1) years

Applications:

• Application must include:
• Cover letter
• Research summary of past accomplishments
• CV
• 1 letter of support (or the names and contact details of 2 referees)
• Applications including all material to be sent via e-mail to: sinergia.brd@chem.uzh.ch (mention specifically the position he/she is applying to and the main PI to whom the application is addressed).