PhD Research Fellow in Protein Biochemistry 1064 views

The Vascular Pathophysiology Lab Headed by Prof. Sandip Kanse, Faculty of Medicine, Institute of Basic Medical Sciences, Department of Molecular Medicine at the University of Oslo invites applications for a 3-4 year position Research Fellowship as a PhD candidate in protein biochemistry.

About the project:

• This group focusses on understanding the role of proteases in cardiovascular diseases such as thrombosis and stroke using biochemical, cellular and molecular techniques and in vivo mouse models.
• The selected candidate will work on a project that is related to the structural analysis of proteases in blood using x-ray crystallography and cryo-electron microscopy.
• The main activities will consist of expression recombinant proteins and their purification, designing and expressing mutants and testing them in relevant assays.
• The aim is to understand activation and inhibition mechanisms of proteases at an atomic level.
• The project will be done in collaboration with the Oslo Structure Biology group

Qualification:

• Applicants must hold a Master’s degree or equivalent in Biochemistry or related science. A Master’s degree (120 ECTS) minimum grade B (ECTS grading scale) according to the Norwegian system or equivalent. The Master’s degree must include a thesis of at least 30 ECTS
• Background and experience in some of the following areas is required: Large scale expression of recombinant proteins in bacteria or eukaryotic cells.
• Protein purification using FPLC and other techniques.
• Design and construction of plasmids and mutagenesis.
• Methods related to determination of protein structure and function. Enzymology.
• Fluent oral and written communication skills in English

How to apply:

Apply online and the application must include:

• Cover letter statement of motivation and research interests
• CV (summarizing education, positions and academic work)
• Copies of educational certificates (academic transcripts only)
• Documentation of english proficiency
• A complete list of publications and academic works
• List of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number)