PhD studentship in Protein Interaction Studies 2065 views

Two PhD fellowships are available in the group of Assistant Professor Amelie Stein, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. The research in the Stein group aims to link protein biophysics and genomics using computational and experimental methods.

1. The PhD fellow will work on disentangling the consequences of missense variants in proteins on their stability, interactions, and function.
2. Both students with focus on experimental work as well as those interested in computational modelling of protein structure and interactions are encouraged to apply. Long-term goals in our research group and the PRISM Centre we are part of include developing predictive and mechanistic models for how genomic variation in protein-coding regions (protein variants) affect the stability, interactions and function of proteins.
3. For an introduction to the research see e.g. our recent review (Stein et al, TiBS, 2019, https://doi.org/10.1016/j.tibs.2019.01.003. Research topics for the PhD projects include:
4. The Ph.D. student(s) will work together with scientists from several disciplines in a highly international environment, thus a good level of spoken and written English is required.
5. Principal supervisor is Associate Professor Jeppe Vinther, Department of Biology, University of Copenhagen, email: jvinter@bio.ku.dk, phone +45 22840780.

The phd position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are:

1. To manage and carry through your research project
2. Attend PhD courses
3. Write scientific articles and your PhD thesis
4. Teach and disseminate your research
5. To stay at an external research institution for a few months, preferably abroad
6. Work for the department 

Requirements

We are seeking motivated and strong applicants with a MSc degree in molecular biology, biochemistry, biophysics, bioinformatics, physics, chemistry or similar fields with prior research experience (e.g. MSc projects) within one or more of these areas:

1. Molecular biology techniques (cloning, transfection, Wester Blots)
2. Yeast genetics

1. Structural bioinformatics, especially with focus on protein interactions or complexes
2. Computational analyses of the effects of protein sequence variation on protein stability, interactions and function

It will also be advantageous to have experience with one or more of the following:

• Yeast-two-hybrid or other high-throughput approaches for protein interaction detection
• The Rosetta software for protein structure modelling
• Machine learning applications to protein modelling 

How to apply

The application, in English, must be submitted electronically by clicking APPLY NOW below.

1. A cover letter (max 1. page) explaining your background, key skills and how they are relevant to our research, and your motivation for applying
2. Curriculum vitae (max 2. pages) including educational background and previous research experience
3. List of publications (including preprints and papers in active preparation)
4. Diploma and transcripts of records (BSc and MSc). If you do not yet hold your MSc and would like to apply, please submit a letter from your supervisor regarding your expected graduation date
5. Contact details for 1-2 former supervisors (no reference letters should be attached)

The deadline for applications is 26 May 2021 23:59 GMT +2.

For specific information about the PhD scholarship, please contact Assistant Professor Amelie Stein (amelie.stein@bio.ku.dk)

General information about PhD program at SCIENCE is available at https://www.science.ku.dk/phd.