PhD and postdoctoral positions are available based in the Division of Immunology to support the program on ‘Immunology of Infectious Diseases in Africa’ under the supervision of Prof. Frank Brombacher, Group Leader, ICGEB Cape Town, and Dr. Reto Guler.The group performs genome-wide transcriptomics on RNA transcripts to identify host drug targets against tuberculosis and leishmaniasis. The goal is to identify host proteins, non-coding RNA (lncRNA, microRNA) and pathways that are subverted by Mycobacterium tuberculosis and Leishmania major to increase its persistence and survival.

The aim is to validate identified drug targets genes in macrophages and experimental mouse models by gain and loss of function studies. In collaborative studies the group further aims to develop an inhalation drug delivery system against tuberculosis.

Applicants should be highly motivated, self-driven and have a strong background in either tuberculosis or leishmaniasis immunology with skills in molecular biology, mouse models and standard immunological techniques.

Funding will be provided by the SARCHi/ICGEB program and the DST/NRF collaborative postgraduate training programme for two years. If interested, please send your CV and motivation letter by email to Dr. Reto Guler (reto.guler@uct.ac.za).

Closing Date: Not Mentioned (apply immeditely)

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