PhD Student (Neurobiology) at the Department: Cellular and Molecular Pathology (Reference no. 259/2015) at German Cancer Research Center, Germany. The following PhD project in neurobiology offers the possibility to investigate the regulatory membrane lipid microenvironment in central nervous system (CNS) regulation of body energy homeostasis and metabolism.
General introduction: Obesity, hyperinsulinemia, and diabetes are well-recognized risk factors for the development of various cancers and other co-morbidities. Glucosylceramide synthase-derived gangliosides are highly expressed components of the neuronal plasma membrane, which are essential for neuronal function.
Neuronal gangliosides are furthermore crucial for proper regulation of energy homeostasis, body weight, and peripheral glucose/insulin metabolism. In fact, neuronal ganglioside deficiency has been shown to contribute to CNS-mediated obesity.
During the current project, the role of CNS gangliosides in the regulation of adipose tissue and body weight homeostasis shall be analyzed. Furthermore, the interaction of gangliosides with neuronal stem cells and adult neurogenesis shall be analyzed in various obesity and diabetes models. The successful applicant will deal with a great variety of methods, ranging from basic molecular biology, immunefluorescence, and cell culture to cutting-edge technologies such as electrophysiology.
Qualification / Requirements –
- The successful applicant has an excellent theoretical background in Cell Biology and Molecular Biology.
- He/ She has excellent hands-on skills in basic lab techniques and is eager and highly motivated to work efficiently in a team of young scientists.
- Previous experience and an exceptional interest in neurobiology/ energy metabolism would be advantageous.
Key Features –
- Interesting, versatile workplace
- International Environment
- Compensation by TV-L
- Opportunities for part-time work
- Flexible working hours
- Good education and training
| Deadline: | December 16, 2015 |
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| More information: | Dr. Viola Nordström phone 06221 42-4357 |