PhD Student Position in Immunology: Topic of the project: Molecular regulation of T cell function by histone deacetylases HDAC1 and HDAC2. We are looking for a motivated and enthusiastic PhD student who is interested to investigate the role of HDAC1 and HDAC2 in the regulation of T helper differentiation. The position is open from October 2015.
Experience in basic tissue culture techniques and molecular biology would be advantageous.
We offer an exciting FWF-funded cutting-edge research project and an international research environment. If you are interested, please contact: wilfried.ellmeier(at)meduniwien.ac.at
Subject: Immunology/T cell biology/Th differentiation
Institute: Medical University of Vienna, Institute of Immunology, Division of Immunobiology
Website: http://www.meduniwien.ac.at/immunologie/ellmeier
Last date: 31.08.2015
Brief description of the Ellmeier Laboratory (Austria):
Our long-term research interest is to characterize molecular mechanisms that regulate the development and function of T cells. We made important contributions to the transcriptional control of Cd8 gene expression and identified that the transcription factor MAZR is an important regulator of CD8 expression as well as of CD4/CD8 lineage development. Moreover, we are interested in elucidating the roles of histone deacetylases (HDACs) in T cells and e.g. we recently identified that CD4+ T cell lineage integrity is regulated by HDAC1 and HDAC2. We have also a long-standing interest in revealing the role of Tec family kinases in the regulation of immune responses. In ongoing studies my team addresses topics like: (1) Transcriptional control of CD4/CD8 cell fate choice; (2) Transcription factor networks regulating peripheral T cell function; (3) Maintenance of T cell lineage identity, integrity and function; (4) Characterization of signaling pathways modulating Th differentiation. The experimental strategies to address our research interests include immunological tools, biochemical and molecular approaches, retroviral-mediated gene transduction into hematopoietic stem cells, and mouse molecular genetics tools.
Contact
- Name:Wilfried Ellmeier
- E-Mail:wilfried.ellmeier(at)meduniwien.ac.at