2 Postdoctoral Positions Available in the Yildirim Lab: Two postdoctoral positions are available in the Yildirim lab for highly motivated and talented applicants who are interested in research involving noncoding RNA mediated epigenetic mechanisms and/or spatial organization of gene expression in mammalian system.
Research Overview / Introduction: The coding capacity of the genome is not controlled solely by DNA sequences, but is rather fine-tuned through epigenetic factors and the nuclear structure. In the Yildirim lab, we study how epigenetic mechanisms, particularly those that are mediated by long noncoding RNAs (ncRNAs), complement gene expression, impact genome stability and define cell fate decisions.
Other research in the lab focuses on understanding how chromatin-nuclear envelope interactions mediate gene expression programs in stem cells. We are interested in defining the molecular bases of these interactions and delineating their significance in driving gene expression and genome functions.
We approach these two main areas of research by utilizing a variety of genetic, cell biological and genomics tools using mouse stem cells and mouse models. In the long run, a detailed understanding of the genetic, epigenetic, and cellular mechanisms that are mediated by long ncRNAs and nuclear structure will allow us to explore their causal roles in disease and cancer.
Requirements: The applicants should hold a PhD or MD/PhD, and have a strong training in genetics, molecular biology, cell biology, developmental biology or epigenetics. Expertise in stem cell biology, imaging techniques, mouse genetics, and bioinformatics are strongly desired. It is also essential that the candidates have a strong first author publication history.
How to Apply: Interested applicants should email their CV and a 1-page cover letter (describing their past accomplishments, research interests and career goals) along with names and contact information of three references to eda.yildirim@duke.edu.
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