15 PhD positions: PoLiMeR (Experimental and Computational Sciences) 1445 views

PoLiMeR is funded through the EU Marie Skłodowska-Curie Innovative Training Network (ITN), which drives scientific excellence and innovation. Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response.

Qualifications:

• Applicant must have (almost) completed master degree in a discipline relevant to the PhD position(s).
• Applicant must demonstrate strong motivation for scientific research in an interdisciplinary and international environment
• Applicant must possess excellent English presentation and writing skills
• Applicant must have good organisational and communication skills, being a team-player
• At the time of recruitment by the host organisation, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to the reference date.

Starting date: April 2019, but it will be possible to start earlier or later between October 2018 and September 2019.

Applications:

• Apply by sending CV and motivation letter to info@polimer-itn.eu (indicate motivation for which PhD position(s) you are applying).

PhD positions

Challenge 1: Enzyme catalysis at the polymer surface

• PhD student 1: Kinetic analysis of enzymes of glycogen metabolism
• PhD student 2: Structural analysis of glycogen fromin vitromodels and patients with Glycogen Storage Diseases
• PhD student 3: Mathematical modelling of glycogen metabolism and glycogen-related disorders

Challenge 2: Combinatorial explosion of molecular species

• PhD student 4: Quantitative and miniaturised assays for structure-resolved lipidomics
• PhD student 11: Development of in vitroliver models for inborn errors in glycogen and fatty-acid metabolism
• PhD student 6: Stoichiometric modularisation of combinatorial lipid metabolism

Challenge 3: Pathway dynamics

• PhD student 9: Instability of glucose production in fatty-acid oxidation defects
• PhD student 12: Interplay between coenzyme and energy metabolism in fatty-acid oxidation defects
• PhD student 8: Dynamic computational modelling of lipid synthesis and storage in the human liver
• PhD student 10: Dietary interventions and compensatory substrate switch in fatty-acid oxidation defects

Challenge 4: Spatial and hierarchical regulation

• PhD student 13: Multi-level regulation of metabolism in fatty-acid oxidation defects
• PhD student 14: Directing signal transduction pathways to establish novel therapies for glycogens storage disease type I
• PhD student 15: The role of autophagy and mTOR signalling in inborn errors of glycogen metabolism in hepatocytes
• PhD student 5: Integration of genome-scale models with signalling networks

Challenge 5: Data and model management

• PhD student 7: Data and model management and information retrieval