PhD Cancer Cell Biologist: Institute of Molecular Genetics ASCR 1692 views

PhD Cancer Cell Biologist: Institute of Molecular Genetics

PhD position at Laboratory of Cancer Cell Biologist Institute of Molecular Genetics ASCR in Prague. The lab use human cells and mouse models to study cellular responses to DNA damage.

Aim is to understand how genome integrity is protected in healthy cells and how defects in these pathways contribute to cancer development.

ORGANISATION/COMPANY: Institute of Molecular Genetics of the ASCR

Area Of Research: Biological sciences, Chemistry, Biochemistry

RESEARCHER PROFILE: First Stage Researcher (R1)

HOURS PER WEEK: 40

Two (02) projects will be opened

Group leader: Libor Macurek

Supervisor: Libor Macurek ([email protected])

Project 1

Project title: The role of Wip1 phosphatase in DNA damage response

Description: Protein phosphatase PPM1D/WIP1 is a negative regulator of the tumour-suppressor p53 and controls termination of the DNA damage response. Amplification of the PPM1D locus or C-terminal truncation of PPM1D promotes breast and ovarian cancer. This project will focus on investigation of molecular mechanisms that control Wip1 function as well as unrevealing new modes of Wip1 action.

Project 2

Title: The role of PLK3 kinase in cell proliferation and response to genotoxic stress

Description: Protein kinases of the Polo-like family are involved in many events of nuclear and cell division. The project will focus on the least explored member of this kinase family, PLK3 that is involved in other cellular functions including DNA repair. Role of PLK3 will be studied using CRISPR/Cas9 mediated gene editing and ATP-analogue sensitive mutants allowing selective inhibition of PLK3.

APPLICATION DEADLINE: 28/02/2018 23:00 – Europe/Brussels