PhD in Quantitative Cell and Developmental Biology 721 views

The Faculty of Science and Institute of Biology at Leiden University is looking for a PhD position in Quantitative Cell and Developmental Biology.

Responsibilities:

• The PhD project will be part of an interdisciplinary, NWO-funded Vici-project that will unravel how modifications of the extracellular matrix, as they can occur for example near tumors, can modify the structure of new blood vessel networks.
• As a developmental cell biologist, the candidate will work closely together with two mathematical modelers. Supported by a senior research technician, will attempt to falsify the predictions of the mathematical models in the wetlab through imaging of cell cultures and zebrafish.
• Experimental techniques include: Cell culture, lab-on-a-chip, zebrafish, in vitro and in vivo imaging using time-lapse microscopy, quantitative reflection microscopy, TIRF, 4D imaging using a VAST system; Fluorescent imaging of dynamic cell behavior, cell morphology and ECM characteristics in vitro and in vivo under the influence of a range of pharmacological and genetic experimental interventions, including ECM characteristics such as stiffness, matrix orientation and acidity using imaging techniques, which will lead to insight in conjunction with the model; Active participation in image analysis and digital annotation of the results.

Requirements:

• Applicant must hold Master’s degree in Cell Biology, Biophysics, Imaging or a related discipline.
• Excellent written and oral proficiency in English;
• Ability and enthusiasm for working both independently and collaboratively in a highly multidisciplinary environment;
• Experience in cell and developmental biology and imaging;
• Keen interest in or experience with image analysis and/or mathematical modeling approaches;
• Fluent interdisciplinary communication skills with scientists in mathematical biology, biophysics and cell biology;

Applications:

Apply online and upload the following additional documents:

• A letter of motivation
• An updated CV
• The letters of recommendation by 1 or 2 former supervisors
• The transcripts of MSc studies