PhD Student: Structure and Dynamics of Chromosomes, MPI 1516 views

PhD Student: Structure and Dynamics of Chromosomes, MPI (Max Planck Institute)

Developmental and Evolutionary Biology & Genetics Structural and Cell Biology

Job Code: 21/03/01_II

Description

The lab of “Structure and Dynamics of Chromosomes” led by Eugene Kim at the Max Planck Institute of Biophysics is seeking a highly motivate PhD student to develop and employ novel single molecule approaches for studying the dynamics of DNA/protein interactions in complex DNA topologies at high spatiotemporal resolution. The candidate will generate and visualize different DNA topologies, such as under-/overwound and entangled DNA structures, with high throughput and investigate how different mechanical (e.g., torsion and tension on DNA) and biological factors (e.g., topoisomerases, BAFs, SMCs etc.) may contribute to the segregation of the sister chromosomes.

The candidate will learn and combine different imaging and manipulation modalities, including total internal reflection fluorescence and scattering microscopy, single molecule super localization, magnetic tweezers.

Requirements / Qualification

1. An outstanding experimentalist with master’s degree of biophysics, physics, optics, biophotonics, physical chemistry, electrical/bioengineering or the like.
2. Prior experience in building/aligning optical setup, programming (LabVIEW, Python, Matlab, C++, etc.) for controlling hardware and/or data analysis.
3. Prior experience/knowledge in enzymology, microfluidics, surface chemistry is a plus but not required.
4. A creative individual with a strong interest in chromatin biophysics and with a motivation to adapt to new research challenges.
5. An independent individual with excellent English communication and writing skills

Fellowship and Application Procedure

The fellowship is in accordance to the Public Sector Collective Agreement Bund (TVöD, E13; 65%). To apply, please send a cover letter (one page maximum), a curriculum vitae, and the contact details of two to three references to Eugene.Kim@biophys.mpg.de until 31.03.2021.