Postdoctoral Research Fellow in Medicinal Chemistry
Postdoctoral position is available to develop small molecule inhibitors for targeted therapies in cancer. We are seeking for highly motivated postdoctoral fellow with very extensive knowledge and experience in synthetic organic chemistry and medicinal chemistry. The candidate will be involved in designing and synthesis of small molecule inhibitors targeting proteins as potential anti-cancer agents with a major focus on synthesis of heterocyclic compounds targeting protein-protein interactions relevant to cancer.

The duties will include design and synthesis of new analogues of existing leads to develop SAR for different classes of lead compounds. The successful candidate must be independent in designing synthetic routes, solving challenging synthetic problems, efficient in synthesizing targeted molecules, analyzing results and SAR data to improve drug-like properties of synthesized compounds. The applicant needs to be experienced in using HPLC, NMR and MS for organic chemistry applications. Successful candidate will be a part of an interdisciplinary team whose research is focused on different stages of pre-clinical development of anti-cancer drug candidates, including biochemical studies, medicinal chemistry, structural biology, molecular modeling, cell-based experiments and animal studies.

How to Apply

A cover letter is required for consideration for this position and should be attached as the first page of your CV and also include 2 to 3 references. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.

Required Qualifications*

Applicant must have PhD in medicinal chemistry or organic chemistry and be a first author on at least 3 publications. This position requires extensive experience and independence in designing synthetic routes for new classes of compounds, solving challenging synthetic problems, development of analogues for selected leads and SAR analysis. In addition expertise in structure-based drug design and ADMET optimization would be a plus. Applicant needs an expertise in using HPLC, NMR and MS for organic chemistry applications. Furthermore, excellent oral and written communication skills in English are required.

Additional Information

Relevant publications:

1. S. He, et a.l, High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction., J. Med. Chem., 2014, 57 (4):1543-56. .

2. Grembecka J, et al., Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol. (2012), 8 (3):277-84.

3. A. Shi, et al., Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, (2012), 120, 4481-9.

Background Screening

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Mission Statement

The University of Michigan Health System improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Application Deadline


U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.