Postdoctoral position in mouse models of immune cell development and disease USA 2015

The Ciofani lab studies the transcriptional regulatory networks that govern inflammatory immune cell development and function.  We are seeking motivated, talented candidates for full-time postdoctoral positions to be held in the Department of Immunology, Duke University Medical Center.

Positions are immediately available in two exciting project areas: (1) A National Multiple Sclerosis Society-funded position aimed at identifying novel genetic mediators of multiple sclerosis (MS).  The project applies an integrative network approach, combining regulatory information from global transcriptomic and chromatin conformation measurements of human CD4 T cells with genome wide association study data to identify and prioritize MS risk-linked genes.

The researcher will apply established protocols as well as develop novel methodologies to achieve this goal.  The study will involve high-throughput sequencing; CRISPR/Cas9 genome targeting; and screening of gene candidates in mouse models of MS, thus providing the successful fellow with experience in several cutting-edge techniques.  The ideal candidate will have a strong background in immunology and/or molecular biology; and be interested in managing an interdisciplinary project focused on the generation and computational analysis of large data sets.(2)  The gene regulatory mechanisms governing inflammatory T cell development, plasticity, and function.  

Our focus is on the role of AP-1 family transcription factors and non-coding RNAs.  The researcher will take advantage of cell culture methods; global genomic regulatory assessments (RNA, accessibility, transcription factor occupancy); and in vivo models of infection and autoimmune disease in gene-deficient animals to perform functional and mechanistic studies.Appointments will be made on a renewable one-year contract with the expectation of at least a three-year commitment. Positions are available immediately and will be filled as soon as possible.


The position requires a PhD in immunology, molecular biology, or a related field with a strong background in mouse models of immune cell development and disease, or molecular biology techniques. Depending on the position, experience with mouse handling, human cell culture, flow cytometry, high-throughput sequencing, and downstream computational analysis will be highly desirable. Extremely motivated individuals with excellent communication skills within 1-3 years of receiving their PhD are encouraged to apply.

How to Apply: 

Interested applicants should email application materials (cover letter, CV, statement of research interests, and the contact information for at least three references) to Dr. Maria Ciofani Please indicate ‘Postdoctoral applicant—Duke Immunology’ in the subject line when applying.

Contact Name: Maria Ciofani

Contact Email:

Deadline to Apply: Friday, July 31, 2015