2 Researcher positions: Computational Chemistry/Computer-Aided Drug Design 1193 views

The Department of Cell and Molecular Biology at Uppsala University has vacant positions available in Jens Carlsson’s group in the computational biology and bioinformatics programme.

About the research:

• Jens Carlsson’s research focuses on using molecular modeling to study protein-ligand interactions, in particular G protein-coupled receptors (GPCRs).
• The GPCR superfamily is a large group of human membrane proteins that plays key roles in physiological processes and are important drug targets.
• The Carlsson group uses structure-based modeling to understand how receptors evolved their functions and to design ligands, often in close collaboration with experimental groups.
• The project is focused on modeling of GPCRs with the goals to understand receptor function at the molecular level and to identify ligands of drug targets.
• The work will involve molecular dynamics simulations to predict receptor structures and how receptors evolved to recognize their ligand. Structure-based virtual screening of large chemical libraries will also be performed to identify ligands of GPCRs.

Requirements:

• Applicant must hold a PhD degree and should have expertise in at least two of these areas: protein structure prediction, molecular docking, molecular dynamics simulations, structure-based drug design.
• Good English language skills and the ability to work in a team are required.
• Experience in modeling of GPCRs and programming/scripting is preferred, but not required.

Applications:

Apply online and the application should include the following:

• A short letter with a description of research interests and how the candidate could contribute to the project.
• CV with complete publication list.
• Copy of PhD certificate.
• Contact information for at least two references.